| 利用"分层法"评价中药复杂体系药效时有关权重设立的讨论 |
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| 引用本文： | 陶佳林 赵玉男 王笑 雷帆 邢东明 杜力军. 利用"分层法"评价中药复杂体系药效时有关权重设立的讨论[J]. 世界科学技术, 2005, 7(1): 33-37 |
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| 作者姓名： | 陶佳林 赵玉男 王笑 雷帆 邢东明 杜力军 |
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| 作者单位： | 陶佳林（清华大学生物科学与技术系药物药理研究室,北京,100084） 赵玉男（清华大学生物科学与技术系药物药理研究室,北京,100084） 王笑（清华大学生物科学与技术系药物药理研究室,北京,100084） 雷帆（清华大学生物科学与技术系药物药理研究室,北京,100084） 邢东明（清华大学生物科学与技术系药物药理研究室,北京,100084） 杜力军（清华大学生物科学与技术系药物药理研究室,北京,100084） |
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| 基金项目： | 清华大学基础研究基金(JC2000050):中药药代动力学方法研究,负责人:杜力军. |
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| 摘 要： | 本文讨论了以分层法进行中药药效评价时权重设立的问题，主要由以下几部分组成：1．建立递阶层次结构；2．构造两两比较判断矩阵；3．计算单一准则下元素的相对权重；4．计算各层元素的组合权重。由于中药作用具有多途径、多靶点的特性，因此评价过程中权重的设立就占有重要位置。它直接影响对被评价对象药效作用的评判。全面解决中药作用多途径、多靶点药效学评价的数学方法，客观量化的评价中药的综合药效，是中药现代化进程中一个值得研讨的命题。
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| 关 键 词： | 中药药效 多途径 多靶点 设立 药效学 评价 中药现代化 权重 直接影响 准则 |
| 修稿时间： | 2004-08-21 |
A Discussion Concerning Establishment of Weight in Assessing TCM Effectiveness of Complex System by Method of Stratification |
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| Tao Jialin,Zhao Yunan,Wang Xiaolei,Xing Dongming and Du Lijun. A Discussion Concerning Establishment of Weight in Assessing TCM Effectiveness of Complex System by Method of Stratification[J]. World Science and Technology(Modernization of Traditional Chinese Medicine), 2005, 7(1): 33-37 |
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| Authors: | Tao Jialin Zhao Yunan Wang Xiaolei Xing Dongming Du Lijun |
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| Abstract: | This article discusses the establishment of weight in the assessment of TCM effectiveness by the method of stratification, which is composed of the following parts: (1) the establishment of hierarchical strata structure, (2) the construction of pair wise comparison decision matrix, (3) the computation of the relative weight of elements under a single norm and (4) the computation of the combined weight of elements in all the strata. The establishment of weight plays a significant part in the assessment since the functions of traditional Chinese medicine is characterized by multi - ways and multi - targets, which is able to directly influence the judgement of the effectiveness of assessed medicaments. It is a subject worthwhile being studied in the progress of the modernization of TCM to generally settle down the mathematic method for the assessment of TCM effectiveness with multi - ways and multi - targets and to assess the comprehensive effectiveness of TCM by means of objective quantization. |
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| Keywords: | effectiveness of TCM weight mathematic method |
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