腹腔灌注化疗联合微波体外聚焦热疗治疗晚期腹盆腔恶性肿瘤近期疗效观察

为观察腹腔灌注化疗联合微波体外聚焦热疗治疗晚期腹、盆腔恶性肿瘤的近期疗效,2005年5月~2007年5月青岛市胶州中心医院放疗科对115例晚期腹、盆腔肿瘤患者进行治疗,随机分为热化疗组(55例)和单纯腹腔化疗组(60例)。结果热化疗组卵巢癌有效率、胃肠癌有效率及总有效率为63.6%、59.1%和60.0%,均明显高于化疗组的46.2%、36.2%和38.3%,差异有统计学意义,P值均<0.05。热化疗组疼痛缓解方面、体质量增加及KPS评分提高等均明显高于单纯化疗组,而食欲减退发生率却明显低于化疗组,差异均有统计学意义,P值均<0.01。热化疗组恶心呕吐的发生率明显低于化疗组,差异有统计学意义,P<0.05;口腔炎、腹泻、骨髓抑制、神经毒副反应及肾功能受损等的发生率热化疗组也低于化疗组,但差异无统计学意义,P值均>0.05。初步观察结果提示,热化疗组无论是肿瘤缓解率、患者生活质量的改善,还是毒副反应的减轻都明显优于单纯腹腔化疗组,值得临床推广应用。

Short-term results of intraperitoneal perfusion clemotherapy combined with microwave hyperthermia for advanced abdominal and pelvic maligances

The objective of this study was to observe the short-term results of intraperitoneal perfusion chemotherapy combined with microwave hyperthermia for advanced abdominal and pelvic malignances. A total of 115 patients with advanced abdominal and pelvic malignances from May 2005 to May 2007 were divided randomly into two groups-peritoneal chemotherapy plus microwave regional hyperthermia group (55 patients) and intraperitoneal chemotherapy alone group (60 cases). CR PR rates with ovarian cancer, gastrointestinal cancer and both were 63.6%, 59.1%, 60%, respectively in thermochemotherapy group and 46.2%,36.2% and 38.3%, respectively in the chemotherapy group (P<0.05). Pain relief, weight gain and KPS score raise of thermochemotherapy were significantly higher than those of chemotherapy alone, and the incidence of anorexia was obviously lower than that in the chemotherapy group, (both P<0.01). Nausea and vomiting of thermochemotherapy occurred significantly lower than those in the chemotherapy group (P<0.05). Stomatitis, diarrhea, myelosuppression, neurotoxicity and renal damage incidence in the thermochemotherapy group were also lower than those in the chemotherapy group, but being not statistically significant. In conclusion, the CR PR rate, improvements in the quality of life of the patients or the drug reaction reduction in the thermochemotherapy group are clearly superior to those of chemotherapy alone. Thermochemotherapy has a definite therapeutic effect, and is worthy of clinical application.