Comparison of diagnostic efficacy between CLE,tissue sampling,and CLE combined with tissue sampling for undetermined pancreaticobiliary strictures: a meta-analysis |
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Authors: | Ya-Dong Gao Ya-Wei Qu |
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Affiliation: | 1. The Clinical College of the General Hospital of Chinese People's Armed Police Forces, Anhui Medical University, Hefei, China;2. Department of Gastroenterology, General Hospital of Chinese People’s Armed Police Force, Beijing, China |
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Abstract: | Objective: The accurate diagnosis of undetermined pancreaticobiliary strictures remains challenging. Current ERCP-guided tissue sampling methods are of low sensitivity. Confocal laser endomicroscopy (CLE) is a new procedure and allows real optical biopsies that may improve the diagnosis of undetermined pancreaticobiliary strictures. The aim of this meta-analysis was to determine the diagnostic yield of CLE, tissue sampling, and CLE combined with tissue sampling for undetermined pancreaticobiliary strictures.Method: Pubmed, Embase, and the Cochrane Library database were reviewed for relevant studies. Pooled estimates of sensitivity and specificity with 95% confidence intervals (CIs) were calculated using the random-effects meta-analysis model. The summary receiver-operating characteristic (SROC) curve was constructed, and the area under the receiver operating characteristic curve (AUC) was calculated.Results: Twelve studies involving 591 patients were enrolled in our analysis. The overall sensitivity and the specificity estimate of CLE for discriminating benign and malignant pancreaticobiliary strictures were 87% (95%CI, 83–91%) and 76% (95%CI, 70–81%), respectively. The AUC to assess the diagnostic efficacy was 0.8705. For tissue sampling, the overall sensitivity and the specificity estimate were 64% (95%CI, 57–70%) and 94% (95%CI, 90–97%), respectively. The AUC to assess the diagnostic efficacy was 0.8040. A combination of both methods increased the sensitivity (93%; 95%CI, 88–96%) with a specificity of 82% (95%CI, 74–89%). The AUC to assess the diagnostic efficacy was 0.9377. There was no publication bias by Deeks’ Funnel Plot with p?=?.936.Conclusions: Compared with tissue sampling, CLE may increase the sensitivity for the diagnosis of malignant pancreaticobiliary strictures. A combination of both can effectively diagnose malignant pancreaticobiliary strictures. |
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Keywords: | Confocal laser endomicroscopy pancreaticobiliary strictures tissue sampling meta-analysis sensitivity |
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