龙胆对小鼠急性肝损伤保护作用的研究

目的:目的:研究龙胆地上部分和根提取物对小鼠急性肝损伤的保护作用。方法:以CCl₄、硫代乙酰胺(TAA)和D-半乳糖胺(D-GlanN)分别给小鼠灌胃造肝损伤模型,观察龙胆地上部分提取物和龙胆根提取物对模型小鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)和碱性磷酸酶(AKP)水平的影响。结果:龙胆地上部分提取物各剂量均可显著降低CCl₄和TAA急性肝损伤小鼠血清ALT,AST和AKP水平(P<0.05),而对D—GlanN模型小鼠无明显作用(P>0.05),并且实验结果与龙胆根提取物作用一致。结论:龙胆地上部分和根提取物对小鼠急性肝损伤均有一定的保护作用,因此,龙胆地上部分可代替根使用。

Hepatoprotective effects of Gentiana scabra on the acute liver injuries in mice

Objective: To study the hepatoprotectwe effect of the aerial parts and the roots of G.scabra on cute liver injury models. Method: Acute liver injury models were induced by CCl₄, TAA and D-GlanN in mice, and the levels of serum enzyme ALT, AST and AKP on acute liver injury mice with extracts of the aerial parts and the roots of G. scabra were determined. Result: Different dosages of the aerial part extract could significantly reduce the levels of serum enzyme ALT, AST and AKP (P< 0.05) on CCl4 and TAA model mice, but the serum enzymes reduction of D-GlanN model mice was not remarkably. Conclusion: The methanolic extracts of the aerial parts and the roots of G. scabra both have certain hepatoprote-ctive effects on acute liver injury models, and so the aerial parts of G.scabra can be used as the suc-cedaneumm of G. scabra roots.