Apogossypolone对乳腺癌MCF-7细胞株放射增敏的体外实验研究 |
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引用本文: | 魏 芳,汪森明,胡丽娟. Apogossypolone对乳腺癌MCF-7细胞株放射增敏的体外实验研究[J]. 肿瘤学杂志, 2012, 18(8): 596-601 |
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作者姓名: | 魏 芳 汪森明 胡丽娟 |
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作者单位: | 南方医科大学珠江医院,广东广州,510282 |
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摘 要: | [目的]探讨Apogossypolone(ApoG2)对乳腺癌MCF-7细胞株的放射增敏作用及其作用机制。[方法]①MTT法检测ApoG2单药对MCF-7细胞的抑制率,确立细胞半数抑制浓度(IC50)。②根据MTT结果选取低浓度(
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关 键 词: | MCF-7细胞 ApoG2 放疗敏感性 凋亡 自噬 乳腺肿瘤 |
收稿时间: | 2012-05-10 |
Radiosensitizing Effect of ApoG2 on MCF-7 Breast Cancer Cell Line in vitro |
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Affiliation: | WEI Fang,WANG Sen-ming,HU Li-juan(Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China) |
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Abstract: | [Purpose]To investigate ApoG2 enhancing radiosensitivity to MCF-7 breast cancer cell line and its possible mechanism.[Methods]①The inhibition of ApoG2 on MCF-7 cells was examined by MTT assay so as to define IC50.②Low dosage(
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Keywords: | MCF-7 cell line ApoG2 radiosensitivity apoptosis autophagy breast neoplasms |
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