肝小静脉闭塞病的临床现状及研究进展

肝小静脉闭塞病(hepatic veno-occlusive disease,HVOD)是造血干细胞移植(hematopoietic stemcell transplantation,HSCT)的主要并发症之一.其发病机制主要是局部高凝状态,主要病理改变是终末肝小静脉的闭塞及肝细胞的坏死.HVOD的确诊依靠肝组织活检.明确并避免危险因素是降低HVOD的发病率及死亡率的主要措施,药物预防效果尚不确切并且多有不良反应.HVOD的治疗以去纤苷的效果最为肯定,其他药物的疗效仍需验证.本文就HVOD的临床现状及研究进展作一综述.

Clinical research of hepatic veno-occlusive disease:current status and future prospects

Hepatic veno-occlusive disease(HVOD)is one of the main complications of hematopoietic stem cell transplantation(HSCT).Its pathogenesis is mainly associated with a local hypercoagulable state,and the main pathological changes are occlusion of terminal hepatic venules and necrosis of liver cells.The diagnosis of HVOD depends on a liver biopsy.Identifying and avoiding the risk factors are main measures to reduce the incidence and mortality of HVOD,since drug prophylaxis lacks exact effect and has significant adverse reactions.Defibrotide is the most effective therapy for HVOD,while the efficacy of other drugs still needs to be verified.In this paper,we will review the current status and future prospects of clinical research of HVOD.