| 宫颈鳞癌组织HPV16/18 感染与多个癌基因产物表达的研究 |
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| 引用本文： | 黄利鸣,石新兰,黎家华.宫颈鳞癌组织HPV16/18 感染与多个癌基因产物表达的研究[J].肿瘤防治研究,2001,28(5):380-382. |
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| 作者姓名： | 黄利鸣 石新兰 黎家华 |
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| 作者单位： | 宜昌三峡大学医学院病理教研室, |
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| 摘 要： | 目的 探讨 HPV1 6、1 8的感染及多个癌基因的激活在宫颈鳞癌发生发展中的作用。方法 采用免疫组化方法对 1 9例慢性宫颈炎、40例宫颈上皮内瘤变 ( CIN)及 70例浸润性宫颈鳞癌进行 E6、PCNA、p5 3、p2 1 ras和 c- myc蛋白检测。结果 CIN 和浸润性宫颈鳞癌组 E6、PCNA、p5 3、p2 1 ras阳性率明显高于慢性宫颈炎、CIN 和 CIN ,而其 c- myc阳性率则明显低于其它几组。结论 HPV1 6、1 8的感染及 PCNA、p5 3、p2 1 ras、c- myc的异常表达与宫颈鳞癌的发生发展密切相关。
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| 关 键 词： | 宫颈鳞癌 人乳头瘤病毒 癌基因产物 |
| 文章编号： | 1000-8578(2001)05-0380-03 |
| 收稿时间： | 2001-3-28 |
| 修稿时间： | 2001-8-21 |
Study of HPV16/18 Infection and Expression of Multiple Oncogene Product in Cervical Squamous Carcinoma |
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| HUANG Li ming,SHI Xin lan,LI Jia hua.Study of HPV16/18 Infection and Expression of Multiple Oncogene Product in Cervical Squamous Carcinoma[J].Cancer Research on Prevention and Treatment,2001,28(5):380-382. |
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| Authors: | HUANG Li ming SHI Xin lan LI Jia hua |
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| Institution: | HUANG Li ming,SHI Xin lan,LI Jia hua Department of Pathology,Medical School of SanXia university,YiChang 443003,China |
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| Abstract: | Objective To study the infection of HPV16/18 and the presence of multiple oncogene on the carcinogenesis of cervical squamous carcinoma.Methods Immunohistochemical method was used to detect E6?PCNA?p53?p 21ras and c myc protein expression in 19 cases of chronic cervicitis?40 cases of cervical intraepithelial neoplasm (CIN) and 70 cases of invasive cervical carcinoma.Results A high positive expression rate of E6?PCNA?p53?p 21ras was found in CINⅢ and invasive cervical carcinoma which c myc positi... |
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| Keywords: | cervical squamous carcinoma Human papillomavirus Oncogene products |
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