| PI3K/Akt与胶质瘤辐射抗性 |
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| 引用本文： | 薛景,刘芬菊.PI3K/Akt与胶质瘤辐射抗性[J].国际放射医学核医学杂志,2005,29(1):40-43. |
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| 作者姓名： | 薛景 刘芬菊 |
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| 作者单位： | 215006 苏州, 苏州大学放射医学与公共卫生学院 |
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| 基金项目： | 苏州大学医学发展基金重点项目资助(EE126031) |
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| 摘 要： | 恶性脑胶质瘤的术后治疗是患者预后生存期延长的关键,如何提高肿瘤组织的辐射敏感性,增强正常组织的辐射抗性是当前肿瘤放射生物学及临床放疗研究的热点。研究资料表明,PI3K/Akt抗细胞凋亡通路的激活提高了部分细胞的辐射抗性,特别在表皮细胞受紫外线照射的研究中提示,辐射产生的活性氧可能是该通路激活的原因之一;电离辐射可能诱导相关的细胞因子通过激活PI3K/Akt通路介导胶质瘤细胞的辐射抗性;PI3K及其相关酶可能通过DNA修复途径发挥抗辐射作用。PI3K/Akt通路的研究可为放射治疗胶质瘤提供新型的增敏药。
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| 关 键 词： | PI3K/Akt 胶质瘤 辐射抗性 |
| 文章编号： | 1001-098X(2005)01-0040-04 |
| 收稿时间： | 2004-10-08 |
| 修稿时间： | 2004年10月8日 |
PI3K/Akt and radioresistance of glioma |
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| XUE Jing,LIU Fen-ju.PI3K/Akt and radioresistance of glioma[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(1):40-43. |
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| Authors: | XUE Jing LIU Fen-ju |
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| Institution: | Radiation Medicine and Public Health School, Soochow University, Soochow 215006, China |
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| Abstract: | s The post operation therapy on the malignant cerebral glioma is a key to the life extension of a patient. It is a hotspot in radiobiology of tumor and radiotherapy to study how to enhance the radiosensitivity of the tumor tissues and increase the radioresistance of the normal tissues. It was found that activation of PI3K/Akt pathway, an anti-apoptosis pathway, may result in enhancement of radioresistance of some cell lines. Particularly, in researches of ultraviolet (UV) radiation on epidermic cells. It was found that the reactive oxygen species(ROS) induced by UV may be one of the causes to activate the PI3K/Akt. Induction of relative cytokines by ionizing radiation may mediate radioresistance of glioma through PI3K/Akt. It was also found that PI3K and relative kinase may enhance radioresistance of cells through DNA repair. In a word, researches of PI3K/Akt pathway may provide some new radiosensitizers for radiotherapy of glioma. |
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| Keywords: | PI3K/Akt glioma radioresistance |
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