冠心病患者血清脂蛋白(a)水平的测定及其临床意义

目的 :探讨血清脂蛋白 (a) Lp(a) ]水平与冠心病 (CHD)的关系。方法 :CHD组患者 39例 ,健康人对照组(CG) 5 2例 ,分别检测血清Lp(a)、总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)、甘油三酯 (TG)、载脂蛋白AI(apoAI)、载脂蛋白B(apoB) ,对检测结果进行统计学分析。结果 :CHD组Lp(a)水平明显高于正常人对照 (P <0 .0 1) ;Lp(a)与TC ,HDL C ,TG ,apoAI,apoB均无明显相关性 (P >0 .0 5 )。结论 :Lp(a)与CHD的发病密切相关 ,检测Lp(a)含量对临床预测和诊断CHD具有重要价值

Detection of serum Lp(a) level of coronary heart disease and its clinical significance

Objective To study the association of human serum Lp(a) level and coronary heart diseases. Methods Objects examined were conposed of 2 groups: CHD (39 cases) and healthy controls (52 cases). Lp(a), TC, HDL C, TG, apoB of two groups were determined and the results were done with statistic analysis. Results The mean serum Lp(a) concentrations (mg·L -1 ) in coronary heart disease group were shown higher significantly than that in the control group (P<0.01). However, there were no significant correlation between the mean serum Lp(a) and the mean serum TC, HDL C, TG, spoAI and aopB (P>0.05). Conclusions Serum Lp(a) level is closely related to the occurrence of coronary heart disease. Lp(a) is a single risk factor for coronary heart disease. Detecting the determination of serum Lp(a) is extremely valuable to the clinical prediction and diagnosis of CHD.