Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus |
| |
| Authors: | Donnio Pierre-Yves Oliveira Duarte C Faria Nuno A Wilhelm Nathalie Le Coustumier Alain de Lencastre Herminia |
| |
| Institution: | Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire, Rue Henri Le Guilloux, 35033 Rennes, France. pierre-yves.donnio@chu-rennes.fr |
| |
| Abstract: | We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
