磁性纳米粒子在肝细胞癌磁共振成像及靶向治疗方面的研究进展

超顺磁性纳米粒子作为新型材料在临床领域应用广泛，如医学成像及诊断、药物靶向治疗、磁热疗等。它不仅可以在肝细胞癌（HCC）的早期作出特异性诊断，更是一种理想的靶向药物纳米载体。介绍了磁性纳米粒子作为靶向药物载体的性质特点、磁共振成像原理、靶向HCC的作用机制等，重点介绍了磁性纳米粒子的表面修饰及功能化，及其在主动靶向药物输送系统中的应用。认为磁性纳米粒子的应用必将在HCC的诊治中发挥更大的作用。

Research progress in magnetic nanoparticles for magnetic resonance imaging and targeted therapy of hepatocellular carcinoma

Superparamagnetic iron oxide nanoparticles （SPIONs） are new materials that have been widely used in medical imaging, targeted therapy, magnetic hyperthermia, etc. SPIONs Can be used not only for specific diagnosis of early -stage hepatocellular carcinoma （HCC） , but also as a desirable targeted drug nanocarrier. The properties of SPIONs as a targeted drug carrier, the principle of magnetic resonance imaging using SPIONs, and the action mechanism of SPIONs in targeting HCC are reviewed, with an emphasis on the surface modification amt tuuetionalization of SP1ONs and their application in active targeted drug delivery system. It is believed that SPIONs will play a greater role in the diagnosis and treatment of HCC.