| 布替萘芬霜剂局部给药对家兔慢性毒性实验研究 |
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| 引用本文： | 李永金,陈素仙,李静,张崇高.布替萘芬霜剂局部给药对家兔慢性毒性实验研究[J].江苏大学学报(医学版),2002,12(3):220-222. |
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| 作者姓名： | 李永金 陈素仙 李静 张崇高 |
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| 作者单位： | 江苏大学医学院药理学教研室,江苏,镇江,212001 |
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| 摘 要： | 目的：观察布替萘芬霜剂长期大剂量皮肤局部使用对家兔的慢性毒性作用。方法：将24只家兔随机分成4组：对照组、布替萘芬高（20％）、中（10％）、低（5％）剂量组，连续皮肤局部使用1个月后，进行全身情况、血液学、血液生化、组织学检查。结果：除敷药的局部皮肤有些异常外，实验组家兔全身情况、血液学参数、血液生化指标、组织学检查与对照组相比均无明显差异。结论：布替萘芬局部给药安全，临床应用可靠。
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| 关 键 词： | 实验研究 布替萘芬 慢性毒性 家兔 局部给药 |
| 文章编号： | 1671-7783(2002)03-0220-03 |
| 修稿时间： | 2002年5月29日 |
Experimental Study on the Chronic Toxicity of Butenafine Cream Local Delivery in Rabbits |
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| LI Yong jin,CHEN Su xian,LI Jing,ZHANG Chong gao.Experimental Study on the Chronic Toxicity of Butenafine Cream Local Delivery in Rabbits[J].Journal of Jiangsu University Medicine Edition,2002,12(3):220-222. |
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| Authors: | LI Yong jin CHEN Su xian LI Jing ZHANG Chong gao |
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| Abstract: | Objective: To observe the chronic toxic effect of butenafine (BT) cream local delivery in rabbits with large dose and long term administration. Methods: 24 rabbits were divided randomly into four groups: control group (with drug free cream), BT high dosage group (20%), BT middle dosage group (10%) and low dosage group (5%). After 1 month continue local drug delivery in rabbits, the systemic condition, hematology, serum biochemistry and histology of rabbits were measured. Results: There were no significant differences in the systemic condition, hematology, serum biochemistry and histology between experimental and control group, except for light abnormity of local skin. Conclutions: Butenafine can be safely local used in clinical trial. |
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| Keywords: | Butenafine Chronic toxicity Rabbit Local drug delivery |
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