有心血管疾病危险因素人群中高尿酸血症的发生率及其相关因素

目的　观察有心血管疾病危险因素人群高尿酸血症的发病情况,以及血清尿酸水平与其他心血管危险因素之间的关系。方法　连续入选2004年6月至2004年12月有心血管危险因素的就诊患者,测定血尿酸水平。分别分析不同性别患者高尿酸血症的患病率,并识别相关的危险因素。结果　共入选1 600名患者,男性821 例,女性779 例,年龄26~99岁。男性高尿酸血症的患病率为20.58%(169/821),女性患病率为30.55%(238/779)。男性高尿酸血症的独立相关因素是高血压、高胆固醇血症、高三酰甘油血症、血肌酐升高和应用利尿剂;女性的独立相关因素是年龄、高血压、高胆固醇血症、低高密度脂蛋白血症、血肌酐升高和应用利尿剂。高尿酸血症患者合并有3种以上危险因素的比例高于无高尿酸血症的患者(男性为76.92%比59.67%;女性为67.64%比46.77%)。结论　有心血管危险因素的人群中高尿酸血症的患病率高;高尿酸血症患者心血管疾病的危险因素具有群聚性;女性高尿酸血症的发生率高于男性;除高血压、高胆固醇血症、血肌酐升高和应用利尿剂外,女性高尿酸血症的独立相关因素还包括年龄和低高密度脂蛋白血症。

Prevalence of Hyperuricemia in Patients with Cardiovascular Risk Factors

Objective The purpose of the present study was to investigate the prevalence of hyperuricemia in people with cardiovascular risk factors and the relationship between serum uric acid levels and the various cardiovascular risk factors. Methods This study was performed through cross-sectional survey. Patients with cardiovascular risk factors were enrolled from June 2004 to December 2004 consecutively. Serum uric acid was measured and data were analyzed to investigate the prevalence of hyperuricemia both in men and women, and to identify the risk factors. Results 1 600 patients were enrolled (821 men and 779 women ranging from 26 to 99 years old). The prevalence of hyperuricemia was 20.58% in men and 30.55% in women. Hyperuricemia was positively correlated with hypertension, hypercholesterolemia, hypertriglyceridemia, high level of serum creatinine, and the administration of diuretics in men, and was positively correlated with age, hypertension, hypercholesterolemia, hypo-HDL cholesterolemia, high level of serum creatinine, and the administration of diuretics in women as well. The proportion of hyperuricemic patients with 3 or more risk factors is higher than that of non-hyperuricemic patients (76.92 vs 59.67% in men; 67.64% vs 46.77% in women). Conclusion The prevalence of hyperuricemia in patients with cardiovascular risk factors is high. Cardiovascular risk factors often cluster in hyperuricemia patients. The prevalence of hyperuricemia in women is higher than that in man. Apart from hypertention, hypercholesterolemia, high level of serum creatinine and the use of diuretics, hyperuricemia are also positively correlated with age and hypo-HDL cholesterolemia in women.