七种仪器测量中央角膜厚度的比较

目的探讨A型超声角膜测厚仪、眼前段光学相干断层扫描仪（anterior segment -optical coherence tomography, AS - OCT）、角膜内皮镜、Orbscan、Pentacam、超声生物显微镜（ultrasound biomicroscope，UBM）和共焦显微镜（confocal microscope）7种仪器测量中央角膜厚度（CCT）的差异和相关性。方法选取无其他眼部疾病的屈光不正患者265例（530眼），分别用A型超声角膜测厚仪、AS—OCT、角膜内皮镜、OrbscanⅡ、Pentacam、UBM和共焦显微镜7种仪器测量CCT，对7组CCT值采用配对t检验分析其他6种仪器与A型超声之间测量中央角膜厚度之间的差异，采用简单线性相关描述其他6种仪器与A型超声测量中央角膜厚度之间的相关性。结果A型超声、AS—OCT、角膜内皮镜、Orbscan、Pentacam、UBM和共焦显微镜7种方法测量CCT值分别为（546．3±32．4）μm、（534．6±30．6）μm、（537．9±29．2）μm、（544．7±34．5）μm、（548．1±40．7）μm、（545．5±32．8）μm和（544．2±28．3）μm。结论与A型超声相比较，AS—OCT、角膜内皮镜、OrbscanⅡ、Pentacam、UBM和共焦显微镜6种仪器的相关性都较高，都可以用来测角膜厚度，但OrbscanⅡ、Pentacam、UBM及共焦显微镜的测量结果和A型超声更接近。

A comparison of seven machines measuring corneal thickness

Objective To investigate the difference of central corneal thickness （CCT） measured by A - mode ultrasound, anterior segment - optical coherence tomography （ AS - OCT） , specular microscope, Pentaeam, Orbscan n , uhrasound biomieroscope （UBM） and eonfocal microscope. Methods CCT in 530 eyes of 265 patients without other ocular disease were measured by A- mode ultrasound, AS- OCT, specular microscope, Orbscan 11 , Pentaeam, UBM and confocal microscope. Paired t test and linear relation analysis were used to analyze the difference or relation of the measured values by A - mode ultrasound and each other method. Results The mean corneal thickness measured by A - mode ultrasound, AS - OCT, specular microscope, Orbscan II , Pentacam, UBM and confocal microscope was （ 546. 3 ± 32.4 ） μm, （534. 6 ± 30. 6 ） μm, （ 537. 9 ±29. 2 ） μm, （ 544. 7 ±34. 5 ） μm, （ 548.1 ± 40. 7 ）μm, （ 545.5 ± 32. 8 ） μm and （54. 2 ± 28. 3） μm. Conclusion There was signifieant difference between A - mode ultrasound and AS - OCT or specular microscope, hut there was no differenee between A - mode ultrasound and other 4 methods. There were positive correlations between A - mode ultrasound and each other method.