药物过敏反应致急性肾功能衰竭临床分析

目的探讨药物过敏反应致急性肾功能衰竭的临床特点。方法选取药物过敏反应致急性肾功能衰竭患者40例,随机分为老年组和青少年组各20例。2组均予常规内科治疗、透析治疗及抗过敏治疗。观察2组病情及预后情况。结果老年组少尿性急性肾功能衰竭发生率及血液透析率均高于青少年组,差异均有统计学意义(P<0.05)。老年组转为慢性肾功能衰竭率及治愈率低于青年组,肌酐(Scr)及尿酸氨水平高于青年组,差异均有统计学意义(P<0.05)。结论在药物过敏反应致急性肾功能衰竭中,老年患者的发病率和病死率都明显高于青少年。在对患者进行抢救治疗时,一定要将内科综合治疗和血液透析相结合,才能对急性肾功能衰竭患者做出及早治疗。

Clinical analysis of acute renal failure caused by drug allergie

Objective To explore the clinical features of acute renal failure caused by drug allergic reactions.Methods 40 cases patients with acute renal failure caused by drug allergic reactions were randomly divided into elderly group and youth group,each of 20 cases.Both groups were ginen conventional treament of medicine,diglysis and antianaphylactic.Obeserred the conditions and prognosis of patients.Results The incidence of oliguric acute renal failure and hemodialysis rate of elderly group were higher those that of youth group,the difference were statistically significant（P〈0.05）.The converted chronic renal failure rate and cure rate of elderly group were lower than those of youth group,and the level of serum creatinine and uric acid of elderly group were higher than those of youth group,the difference were both statistically significant（P〈0.05）.Conclusion In the acute renal failure caused by allergic reactions,the incidence rate and fatality rate of elderly group are higher than that of youth group.During the rescue of acute renal failure caused by drug allergies,must combined comprehensive medical treatment with hemodialysis,only in this way,can cure the acute renal failure as soon as possible.