| 苯唑青霉素对丁胺卡那毒素药动学的影响 |
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| 引用本文： | 阚全程 王玲忠. 苯唑青霉素对丁胺卡那毒素药动学的影响[J]. 中国药学杂志, 1994, 29(6): 347-350 |
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| 作者姓名： | 阚全程 王玲忠 |
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| 作者单位： | 河南医科大学第一附属医院药剂科 |
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| 摘 要： | 采用微量微生物法对丁胺卡那霉素（AMK）单用及AMK与苯唑青霉素（OXA）合用后，兔体内AMK血药浓度进行测定；药时数据用MCPKP软件经IBM计算机处理，并对两组药动学参数进行了统计学处理，结果表明OXA对AMK的药动学有显著的影响。
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| 关 键 词： | 丁胺卡那霉素 苯唑青霉素 药动学 |
| 收稿时间： | 1993-06-16; |
Influence of oxacillin on pharmacokinetics of amikacin on rabbits |
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| KAN Quan-cheng,WANG Ling-zhong, ZHANG Xian-jian. Influence of oxacillin on pharmacokinetics of amikacin on rabbits[J]. Chinese Pharmaceutical Journal, 1994, 29(6): 347-350 |
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| Authors: | KAN Quan-cheng WANG Ling-zhong ZHANG Xian-jian |
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| Affiliation: | Department of Pharmacy ;the First AffiliatedHospital of Henan Medical University;Zhengzhou 450052 |
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| Abstract: | Amikacin(AMK)in the serum of rabbits was determined by the improved microbiol-ogy method and was compared with combination of AMK and oxacillin(OXA).The concentrationtime were disposed with MCPKP propram and IBM microcomputer,The results showed thatOXA had apparently influence on pharmacokinetics of AMK in rabbits. |
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| Keywords: | amikacin oxacillin pharmacokinetics |
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