Estimating vaccine effectiveness in preventing laboratory‐confirmed influenza in outpatient settings in South Africa, 2015 |
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| Authors: | Johanna M McAnerney Sibongile Walaza Stefano Tempia Lucille Blumberg Florette K Treurnicht Shabir A Madhi Ziyaad Valley‐Omar Cheryl Cohen |
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| Institution: | 1. National Health Laboratory Services (NHLS), National Institute for Communicable Diseases (NICD), Johannesburg, South Africa;2. Influenza Division, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA;3. Influenza Program, U.S. Centers for Disease Control and Prevention, Pretoria, South Africa;4. Faculty of Health Sciences, Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa;5. Division of Medical Virology, Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa |
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| Abstract: | Trivalent seasonal influenza vaccine effectiveness during the 2015 season in South Africa was assessed using a test‐negative case control study design. Influenza A(H1N1)pdm09 was the dominant circulating strain. Overall influenza vaccine coverage was 3.2% (29/899). The vaccine effectiveness estimate, against any influenza virus infection, adjusted for age, underlying conditions and timing within season was 46.2% (95% CI: ?23.5 to 76.5), and 53.6% (95% CI: ?62.6 to 80.3) against influenza A(H1N1)pdm09. |
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| Keywords: | effectiveness influenza vaccine |
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