儿童呼吸道标本中常见真菌的鉴定及耐药性监测

目的：了解我院儿童呼吸道标本中常见真菌感染的种类及耐药性情况，以便指导临床合理用药．方法：应用YBC鉴定卡对从呼吸道中分离出的665株真菌进行鉴定，用ATB-FUNGS 2 INT武条进行药物敏感实验。结果：665株真菌中白色念珠菌占57．1％，其次是热带念珠菌、光滑念珠菌，克柔念珠菌，分别为24．8％、16．2％、1．4％。呼吸科、心内科、新生儿科、血液科真菌的检验率分别为：30．1％、13．5％、13．1％、12．1％；665株真菌对氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑总的敏感率分别为93．4％、88．8％、89．6％、75．2％。结论：真菌感染呈上升趋势。主要致病真菌对氟胞嘧啶、两性霉素B、氟康唑的敏感性较高；对伊曲康唑的敏感性较低，应引起临床医生的重视。

Identification and monitoring drug resistance of fungus in respiratory tract specimen in children

Objective:To understand the denomination of fungous infection and drug resistance in respiratory tract specimen at our hospital.Methods:665 fungi from Respiratory Tract specimen were identified by YBC verification card and drug sensitive experiment by ATB-FUNGS 2 INT trial. Results:Candida albicans occupied 57.1% in 665 fungi, Candida tropicalis,slick Monilia and Candida kruse occupied 24.8%?16.2% and 1.4% respectively.Respiration department,medical department, neonatorum department and blood department were 30.1%?13.5%?13.1% and 12.1% respectively.The sensitive rate of 665 fungi to 5FC,AMB,FAC and ITR was 93.4%?88.8%?89.6% and 75.2% respectively.Conclusion:Fungous infection and drug resistance are ascending tendency. Sensitivity of fungus to 5FC, AMB,FAC is comparatively high,sensitivity of fungus to ITR is comparatively low.Must be enhanced attention in the clinic.