GERD患者内镜、病理改变与食管测压及pH动态监测之间关系的研究

目前，对GERD（GastoesophagealRefluxDisease，GERD）有不少研究报道，如GERD患者的24h食管pH动态监测、压力测定、内镜和病理等，但对它们之间关系的研究却无系列报道。据称，食管pH动态监测较其它任何临床诊断方法都有更高的敏感性和特异性，被认为是诊断GER的“金标准”。本研究即利用这一“金标准”对GERD患者进行食管PH动态监测及食管压力测定，同时研究其与内铺表现及病理改变之间的关系。1对象与布法1．1研究对象1．1．1正常对照组选择无胃肠肝胆疾病，无食管返流症状、无腹部手术史，心电图、血尿常规、内镇及病理检查…

STUDY OF ENDOSCOPIC AND HISTOLOGICAL CHANGES IN GERD PATIENTS USING ESOPHAGEAL MANOMETRY AND 24 HOUR AMBULATORY pH MONITORING

In order to examine the severity of reflux esophagitis and the methods of manometry and 24 hour ambulatory pHmonitoring, 100 gastroesophageal reflux disease (GERD) patients were examined. The results were compared with acontrol group which consisted of 30 healthy individuals. Endoscopy was performed, and esophageal mucosa biopsieswere taken in all patients. Esophageal manometry was recorded using a four tune water perfused system. The severi-ty of esophagitis, determined by both endoscopy and histology, was related to the amplitude of esophageal perista1ticwaves, in partictilar the cardioesophageal sphincter (CES) dysfunction (P < 0. 01), 24 hour reflux total score. Wehave concluded that the severity of reflux esophagitis is related to the duration of reflux, which in turn is associatedwith the impairment of esophageal body motility and CES dysfunction.