| Abstract: | Penetration of six labeled amino acids into the tissues of different parts of the brain and their incorporation into proteins were investigated in sexually mature rats exposed to acute hypoxia at a certain stage of antenatal development. Depression of protein synthesis, mainly in the hypothalamus and cerebral cortex, was characteristic of the experimental animals, and correlated with disturbances of their conditioned-reflex activity. Disturbances of the function of the blood-brain barrier were found in the experimental animals with the aid of labeled amino acids and labeled phosphate, but permeability of the other tissue-blood barriers was unchanged.Moscow Research Institute of Psychiatry, Ministry of Health of the RSFSR. (Presented by Academician of the Academy of Medical Sciences of the USSR P. D. Gorizontov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 10, pp. 416–419, October, 1977. |
