| 阴茎鳞癌中survivin和caspase-3蛋白的表达及其与腹股沟淋巴结转移的关系 |
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| 引用本文： | 郑力强,韩向春,张凯.阴茎鳞癌中survivin和caspase-3蛋白的表达及其与腹股沟淋巴结转移的关系[J].西北国防医学杂志,2010,31(2):114-116. |
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| 作者姓名： | 郑力强 韩向春 张凯 |
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| 作者单位： | 1. 解放军251医院皮肤科,河北,张家口,075000
2. 河北北方学院附属二院病理科 |
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| 摘 要： | 目的：探讨阴茎鳞癌中survivin和caspase-3蛋白的表达及其与肿瘤细胞凋亡和腹股沟淋巴结转移的关系。方法：用免疫组化SP法检测survivin和caspase-3蛋白在31例阴茎鳞癌组织（其中腹股沟淋巴结转移14例）及15例正常阴茎组织的表达情况。结果：阴茎鳞癌组织中survivin的表达显著高于正常阴茎组织（P〈0.01）;而caspase-3在阴茎鳞癌组织中表达显著低于正常阴茎组织（P〈0.05）;survivin表达与临床分期和淋巴结转移有关（P〈0.01和P〈0.05）;与年龄、病理分级无关（P〉0.05）。survivin与caspase-3表达呈负相关（P〈0.01）。结论：survivin、caspase-3可能参与了阴茎鳞癌的发生发展。
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| 关 键 词： | 阴茎癌 survivin caspase-3 淋巴结转移 |
Expressions of survivin and caspase-3 in penile squamous cell carcinoma and their relationship with inguinal lymphnode metastasis |
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| ZHENG Li-qiang,HAN Xiang-chun,ZHANG Kai.Expressions of survivin and caspase-3 in penile squamous cell carcinoma and their relationship with inguinal lymphnode metastasis[J].Medical Journal of National Defending Forces in Northwest China,2010,31(2):114-116. |
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| Authors: | ZHENG Li-qiang HAN Xiang-chun ZHANG Kai |
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| Institution: | ZHENG Li-qiang,HAN Xiang-chun,ZHANG Kai.(Department of Dermatology,251 Hospital of PLA,Zhangjiakou 075000,China) |
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| Abstract: | Objective: To study the expressions of survivin and caspase-3 in penile squamous cell carcinoma and explore the relationship with inguinal lymphnode metastasis.Methods: The expressions of survivin and caspase-3 genes were detected in 31 cases of penile squamous cell carcinoma by using immunohistochemical methods of SP,including 14 cases with lymphnode metastasis and 15 cases of normal penis tissues.Results: The expression of survivin was significantly higher in penile squamous cell carcinoma than that in no... |
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| Keywords: | survivin caspase-3 |
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