E-rosettes in aging: meta-analysis of the literature |
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Authors: | D Brohée |
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Institution: | Department of Internal Medicine, C.H.U. André Vésale, Montigny-le-Tilleul, Belgium. |
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Abstract: | In this meta-analysis of the literature, it is affirmed that aging is associated with a small but significant decline in peripheral E-rosette-forming cells while high affinity E-rosettes (active or early rosettes) increase. The author speculates that this differential age effect may reflect the abnormal capping behaviour of E-rosettes or a change in the cell surface charge properties. A type II error is a common trait of the reviewed studies and could well explain the great number of reports concluding that E-rosette-forming cells are unaltered in the elderly. |
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