Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors |
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| Authors: | Marastoni M Bazzaro M Bortolotti F Tomatis R |
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| Affiliation: | Department of Pharmaceutical Sciences, University of Ferrara, Italy. |
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| Abstract: | A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease. |
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