462例药品不良反应回顾性分析

目的：分析我院药品不良反应（ADR）发生特点和相关因素，确定来年ADR监测工作方向。方法：对我院2007年度收集到的462例ADR报告进行统计分析。结果：ADR报告中20至59年龄段构成比最高；ADR涉及的药品151种，其中抗感染类药物引起的ADR占总例数的74．68％（345例），中成药引起的ADR次之；静脉给药的ADR占72．08％（333例）是引起ADR的主要途径；临床表现以皮肤及其附件损害为主，其次是消化系统损害。结论：临床应重视ADR的监测和报告工作，促进合理用药、减少和避免ADR的发生。

Retrospective Analysis of 462 Cases of Adverse Drug Reactions

Objective： To analyze the characteristics and related factors of adverse drug reactions （ADRs） in our hospital and establish the way of clinical ADR monitoring in the next year. Method： A total of 462 ADR reports collected in 2007 were statistically analyzed. Result： Among the 462cases of ADR, the patients at the age of 20 to 59 had the highest incidence. The drugs that induced ADR totaled 151 kinds. 74.68% （345cases） were induced by anti -infective drugs, followed by traditional Chinese drug preparations; 72.08% （333cases）were induced by intravenous injections. ADRs were mainly manifested in skin and local lesions, next in alimentary system lesions. Conclusion： In order to reduce and avoid the occurrence of ADR and promote the rational use of drugs, clinical departments should attach great importance to the monitoring and report of ADR.