替米沙坦对高血压患者左心室重构及血浆B型钠尿肽的影响

目的探讨替米沙坦对左心室重构和血浆BNP浓度的影响。方法选取高血压患者94例,其中不伴左室肥厚（LVH）患者44例,伴LVH患者50例,健康对照组46例。高血压患者给予替米沙坦80mgqd治疗32周。所有对象治疗前后均测左心室重量指数（LVMI）,BNP,射血分数（EF）,用SPSS13.0进行统计分析。结果高血压无LVH组及有LVH组治疗前后各指标有明显差异（P〈0.05）,对照组无明显差异（P〉0.05）;BNP的变化值与LVMI和EF的变化值正相关。结论无高血压者、高血压不伴和伴左室重构者BNP,EF具有明显差异,血浆BNP水平可反映左室重构和左心功能。替米沙坦对抑制和逆转左室重构,改善心功具有显著作用。

Effect of Telmisarten on Left Ventricular Remodeling and B-type Natriuretic Peptide of the Patients with Hypertension

Objective To study the effect of telmisarten on left ventricular remodeling and plasma b-type natriuretic peptide （BNP）.Methods 94 cases with hypertension formed the experiment group,including 44 cases without left ventricular hypertrophy （LVH） and 50 cases with LVH;46 normal formed the control group;telmisarten,80mg,once a day,was administrated to cases in the experiment group and the course lasted for 32 weeks.;LVMI,BNP and ejection fracture （EF） of all the cases in both groups were detected before and after treatment and the results were statistically analyzed by the software SPSS13.0.Results There existed obvious differences in each index before and after treatment between the patients with hypertension without LVH and those with hypertension and LVH （P〈0.05）,and no obvious difference was found in control group （P〉0.05）;the change value of BNP was positively correlated with that of EF.Conclusions The BNP and EF of patients with no hypertension and patients with hypertension and left ventricular remodeling or with hypertension but without left ventricular remodeling are of significant difference,the plasma BNP level can reflect left ventricular remodeling and left ventricular function;telmisarten is effective in inhibiting and reversing left ventricular remodeling and in improving cardiac function.