温筋通对链脲佐菌素糖尿病大鼠血糖及坐骨神经终末期糖基化终产物的影响 |
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引用本文: | 郭赛珊,唐代屹,梁晓春,张建伟,孙仁宇,张宏.温筋通对链脲佐菌素糖尿病大鼠血糖及坐骨神经终末期糖基化终产物的影响[J].中国中西医结合杂志,2002,22(2):119-121. |
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作者姓名: | 郭赛珊 唐代屹 梁晓春 张建伟 孙仁宇 张宏 |
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作者单位: | 1. 中国医学科学院中国协和医科大学北京协和医院中医科,北京,100730 2. 中国医学科学院中国协和医科大学基础研究所病理生理研究室 |
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基金项目: | 本课题为国家卫生部科研基金资助课题(No.98-1-1052) |
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摘 要: | 目的:观察中药复方温筋通过糖尿病大鼠血糖、坐骨神经终末期糖基化终产物的影响。方法:采用链脲佐菌素糖尿病大鼠模型,随机分为预防组和治疗组,给予温筋通灌胃,并以氨基胍作为对照,治疗12周,观察温筋通过糖尿病大鼠血糖和坐骨神经终末期糖基化终产物的影响。结果:温筋通预防组和治疗组血糖、温筋通预防组和氨基胍组坐骨神经终末期糖基化终产物,均较模型组为低(P<0.01);氨基胍组血糖高于温筋通预防组(P<0.05),与模型组比较,差异无显著性(P>0.05)。结论:温筋通可能通过降低血糖、抑制终末期糖基化终产物在神经组织中的形成,从而预防糖尿病周围神经病变。
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关 键 词: | 温筋通 糖尿病周围神经病变 糖尿病 大鼠 血糖 糖基化终产物 链脲佐菌素 |
修稿时间: | 2001年4月11日 |
Effect of Wenjingtong Composita on Blood Glucose and Advanced Glycosylation End Products in Sciatic Nerve of Streptozotocin-Induced Diabetic Rats |
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Authors: | GUO Sai shan TANG Dai yi LIANG Xiao chun |
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Institution: | Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730. |
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Abstract: | OBJECTIVE: To investigate the effect of Wenjingtong Composita (WJTC) on blood glucose and advanced glycosylation end products (AGEs) in sciatic nerve of streptozotocin (STZ)-induced diabetic rats. METHODS: STZ-induced diabetic rats were randomized to WJTC prevention group and WJTC treatment group. The levels of blood glucose and AGEs in sciatic nerve of the animals were checked after 12 weeks treatment and compared with that of aminoguanidine (AG) treatment group. RESULTS: Blood glucose level in the WJTC prevention and treatment group, and AGEs in sciatic nerve of the WJTC prevention group and the AG group were lower than those of the non-treated group (P < 0.01). Blood glucose level in the AG group was higher than that in the WJTC prevention group (P < 0.05), but was not significantly different from that in the non-treated group (P > 0.05). CONCLUSION: WJTC might prevent diabetic peripheral neuropathy by decreasing blood glucose and inhibiting AGEs formation in sciatic nerve in STZ-induced diabetic rats. |
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Keywords: | Wenjingtong Composita diabetic peripheral neur opathy diabetic rat blood glucose advanced glycosylation end products |
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