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Hemoglobin adducts of benzo[a]pyrene diolepoxide in newspaper vendors: association with traffic exhaust |
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| Authors: | Pastorelli Roberta; Restano Jolanda; Guanci Marco; Maramonte Monica; Magagnotti Cinzia; Allevi Riccardo; Lauri Davide; Fanelli Roberto; Airoldi Luisa |
| Institution: | Laboratory of Molecular Toxicology, Istituto di Ricerche Farmacologiche Mano Negri Via Eritrea 62, 20157 Milan, Italy 1General Practice Research Unit, Istituto di Ricerche Farmacologiche Mano Negri Via Eritrea 62, 20157 Milan, Italy 2Laboratory of Environmental Pharmacology and Toxicology, Istituto di Ricerche Farmacologiche Mano Negri Via Eritrea 62, 20157 Milan, Italy |
| Abstract: | Benzoa]pyrene diol epoxide adducts with hemoglobin (Hb) weremeasured to detect human exposure to environmental benzoa]pyrenefrom traffic exhaust. Benzoa]pyrene tetrahydrotetrols (BPTs)released from Hb after acid hydrolysis were quantitated by gaschromatography-mass spectrometry after immunoaffinity chromatography.Fifty three newspaper vendors were enrolled. The median adductconcentration was 0.3 fmol BPTs/mg Hb in high density traffic-exposedvendors and |
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