| 以ABC膜转运蛋白为靶点的中药逆转肿瘤多药耐药的研究现状 |
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| 引用本文： | 张勇,许建华. 以ABC膜转运蛋白为靶点的中药逆转肿瘤多药耐药的研究现状[J]. 环球中医药, 2009, 2(5): 334-339 |
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| 作者姓名： | 张勇 许建华 |
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| 作者单位： | 上海中医药大学附属普陀医院肿瘤科,200062;上海中医药大学附属普陀医院肿瘤科,200062 |
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| 基金项目： | 上海市普陀区卫生系统自主创新科研资助项目 |
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| 摘 要： | 肿瘤细胞多药耐药是导致肿瘤化疗失败的主要原因之一,其机制异常复杂,是多基因、多步骤综合作用的结果,寻找高效低毒的多药耐药逆转剂已成为肿瘤研究领域的热点,本文主要从ABC膜转运蛋白介导的多药耐药途径,总结近几年中药对这个经典途径的逆转作用的研究。
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| 关 键 词： | ABC膜转运蛋白 多药耐药 中药 |
The research progress of reversal effects concerning traditional Chinese medicine on ATP-binding Cassette(ABC) transporter proteins-Mediated tumor multidrug resistance |
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| ZHANG Yong,XU Jian-hua. The research progress of reversal effects concerning traditional Chinese medicine on ATP-binding Cassette(ABC) transporter proteins-Mediated tumor multidrug resistance[J]. Global Chinese Medicine, 2009, 2(5): 334-339 |
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| Authors: | ZHANG Yong XU Jian-hua |
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| Affiliation: | ZHANG Yong, XU Jian- hua.( Putuo Hospital Affiliated to Shanghai University of TCM , Shanghai 200062, China) |
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| Abstract: | Multidrug resistance of tumor cells is the main cause of failure of cancer chemotherapy, which mechanism is complicated and results from the multiple action of multi-step and multi-gene.Finding the highly efficient and low cytotoxic drugs has become a focus in cancer research.This paper reviewed the reversal effects of traditional Chinese medicine on ATP-binding cassette（ABC） transporter proteins-mediated tumor multidrug resistance. |
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| Keywords: | ATP-binding cassette（ABC） transporter proteins Multidrug resistance Traditional Chinese medicine |
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