联合检测血清GLU、TC和CRP在糖尿病并发冠心病诊断中的价值

目的探讨血清葡萄糖（GLU）、胆固醇（TC）和C-反应蛋白（CRP）联合检测对糖尿病并发冠心病早期的预示和诊断价值。方法分别收集正常对照组（35例）、糖尿病组（85例）、糖尿病并发冠心病组（58例）患者血清，用美国BECKMAN（贝克曼）CX-7全自动生化分析仪检测GLU和TC，用i-CHROMAReader免疫荧光分析仪测定CRP。结果正常对照组：GLU（5．29±0．15）mmol／L、TC（4．20±1．03）mmol／L、CRP（0．68±0．30）mg／L，糖尿病组：GLU（8．33±0．31）mmol／L、TC（4．98±1．121mmol／L、CRP（2．5l±1．311ingle，糖尿病并发冠心病组：GLU（9．98±1．24）mmol／L、TC（5．02±0．871mmol／L、CRP（5．29±1．26）mg／L。糖尿病组、糖尿病并发冠心病组的GLU、CRP均明显高于正常对照组（P〈0．01）。糖尿病组的Tc与正常对照组比较差异无显著性（P〉0．05），糖尿病并发冠心病组的GLU、TC、CRP均明显高于糖尿病组（P〈0．01）。结论联合检测GLU、TC和CRP水平，在预测糖尿病并发动脉粥样硬化性心血管疾病患者中具有重要的临床意义，对冠心病发病的早期诊断有一定的预示作用和诊断价值。

Study on the diagnosis of the serum GLU, TC, CRP to diabetes complicated with coro-nary heart disease patients

Objective To explore the diagnosis value of serum GLU, TC, CRP to diabetes complicated with coronary heart disease patients. Methods Determination was made to serum GLU, TC, CRP for normal group as control （35 examples ）, the diabetic group （85 examples） and diabetes mellitus complicated with coronary heart disease group （ 58 examples ） respectively. GLU and TC were tested with BECKMAN CX-7 automatic biochemical analyzer. CRP was detected with i-CHROMA Reader immune fluorescence analyzer. Results The indexs of normal control group were GLU（5.29 ±0.15） mmol/L, TC（4.20 ± 1.03） mmol/L, CRP （0.68 -＋ 0.30）mg/L. The indexs of diabetic group were GLU （8.33 ± 0.31）mmol/L, TC（4.98 ± 1.12） mmol/L, CRP（2.51 ± 1.31） mg/L. The indexs of diabetes mellitus complicated with coronary heart disease group were GLU（9.98 ± 1.24）retool/L, TC（5.02 ± 0.87） mmol/ L, CtlP（5.29 ± 1.26）mg/L respectively. The GLU , CRP of diabetic group and diabetic patients with coronary heart disease group were significantly higher than those in normal control group （ P〈 0.01 ）. But the TC of diabetic group and normal control group had not difference （P〉 0.05）. The GLU, TC, CRP of diabetes mellitus complicated with coronary heart disease group were higher than those in the diabetic group（P 〈 0.01）. Conclusion The joint detection of GLU, TC and CRP has a preferable clinieal value in the prediction and diagnosis of diabetes patients with atheroselerotic cardiovascular disease.