左炔诺孕酮对36例功能失调性子宫出血的疗效观察

目的探讨左炔诺孕酮（商品名：毓婷）治疗功能失调性子宫出血的临床疗效。方法选择2009年1月-2011年1月期间我院妇科门诊诊断为同绝经期无排卵性功血患者56例，用炔诺酮（妇康片）口服治疗效果不理想者36例，改用毓婷口服治疗3个月经周期。观察止血时问，停药后1个月、3个月随访观察月经量、月经周期变化；并对用药前后Hb、ALT、AST、BUN、CRE进行监测。结果毓婷口服6小时内迅速止血率为69．44％，24-48小时内止血率为30．56％，停药后1个月治疗有效率为91．66％，3个月有效率为72．22％，用药前与用药3个月后Hb、ALT、AST、BUN、CRE结果比较，Hb明显上升，用药前后存在统计学差异（P〈0．05lALT、AST、BUN、CRE无统计学差异（P〉0．05）。结论毓婷治疗功血近期效果较好，止血效果明显，用药期间副作用少，远期效果尚需进一步观察。

The efficacy of 36 cases of dysfunctional uterine bleeding treatment by levonorgestrel

Objective To study the clinical efficacy of lcvonorgestrel （brand name： Yu Ting） intreatment for dysfunctional uterine bleeding （DUB）. Methods 56 cases diagnosed as peri-menopausal patients with anovulatory DUB by gynecology outpatient department in our hospital from January 2009 to January 2011 were treated with oral administration of norethisterone, but no good effect was found in 36 cases, then changed to take levonorgestrel for 3 menstrual cycles. The bleeding time, 1 month after treatment, 3 months follow-up observation of menstrual flow, menstrual cycle changes were observed, and the levels of Hb, ALT, AST, BUN and CRE before and after treatment were also monitored. Results The rapid hemostatic rate of Yu Ting orally taking for 6 hours was 69.44%, hemostatic rate during 24 - 48 hours was 30.56%.The effective rate 1 month after treatment was 91.66%, the one of 3 months was 72. 22%, there was a significant difference among them （P〈 0.05）; 3 months before and after treatment, the levels of lib, ALT, AST, BUN and CRE were compared, Hb level significantly increased after treatment, with a significant difference （P〈 0.05）; there was no significant changes in levels of ALT, AST, BUN and CRE （P 〉 0.05）. Conclusion Levonorgestrel has good effects in treatment for dysfunctional uterine bleeding, obvious results in hemostasis, a low incidence rate of side effects during treatment, but long- term effects need further observation.