宫颈电环锥切术对生育能力及妊娠结局的影响

目的探讨宫颈电环锥切术（LEEP）对宫颈上皮内瘤变（CIN）患者的生育能力及妊娠结局的影响。方法2009年1月-2011年8月于我院因CIN住院治疗的患者20例，给予LEEP治疗，作为观察组，同时随机抽取我院孕前门诊同期内就诊的无妇科手术史的20例健康孕妇，作为对照组，观察妊娠情况及妊娠结局。结果观祭组患者的妊娠率为85％（17／20），对照组健康孕妇的妊娠率为90％（18／20），两组妊娠率比较差异无显著性（P〉0．05）。观察组剖宫产率显著高于对照组（P〈0．05），两组患者流产发生率、早产发生率、胎膜早破发生率以及小于胎龄儿的发生率比较，差异无显著性（P〉0．05），两组患者中无新生儿死亡发生。结论LEEP对CIN患者的生育能力无明显影响，不增加流产率、早产率、胎膜早破及小于胎龄儿发生率。

Effect of loop eleetrosurgical excision procedure on outcome of subsequent fertility and pregnancy

Objective To investigate the effects of cervical loop electrosurgical excision procedure （LEEP） to fertility and pregnancy outcome of patients with cervical intraepithelial neoplasia （CIN）. Methods 20 inpaticnts of CIN from January 2009 to August 2011 were given the LEEP treatment, as the observation gronp, while other 20 healthy pregnant women randomly selected within the same period of the pregnancy out-patient hospital treatment without history of gynecological surgery, were observed as the control group, the observed pregnancy rate and pregnancy outcome were examined. Results The pregnancy rate of the observation group of 20 patients was 85% （17/20）, pregnancy rate was 90% （18/20） in the control group, there was no significant difference （P〉 0.05）. Cesarean section rate of the observation group was significantly higher than that in the control group （P〈 0.05）, and there was also no significant difference in abortion incidence, incidence of preterm premature, rupture of membranes incidence and the incidence of small for gestational age （SGA） children in two groups（P〉 0.05）, no neonatal deaths occurred in the patients of two groups. Conclusion LEEP has no significant effect on the fertility of the CIN patients, without increasing the abortion rate, the rate of preterm birth, premature rupture of membranes, and incidence of SGA children.