血管内皮生长因子在慢性泪囊炎粘膜中的表达

目的:探讨血管内皮生长因子(VEGF)在泪囊慢性炎症组织中的表达,初步探讨慢性泪囊炎粘膜增生的发病机理。方法:应用免疫组化方法对12例慢性泪囊炎粘膜组织中VEGF的表达进行标记,分析粘膜不同部位VEGF的表达情况。选8例正常泪囊粘膜作为对照。结果:VEGF主要表达于上皮基底细胞层,阳性率为44.3%±7.6％,明显高于粘膜表皮和结缔组织间质(阳性率分别为16.9%±4.6％和15.2%±4.9％)(P<0.05),在正常粘膜中未见表达。结论:VEGF可能在慢性泪囊炎粘膜增生的病理过程中发挥重要的作用。

Expression of vascular endothelial growth factor in chronic inflammatory mucosa of lacrimal sac

AIM: To study the expression of vascular endothelial growth factor (VEGF) in inflammatory mucosa of lacrimal sac. METHODS: Immunohistochemical S-P method was used to examine the expression of VEGF in the mocusa from 12 patients with chronic dacryocystitis and 8 volunteers. RESULTS: The positive rates of VEGF expression in different parts of the mocusa were: basal lamina: 44.3%±7.6％; surface epithelium: 16.9%±4.6％; connective tissue: 15.2%±4.9％, all normal mocusa of 8 cases were negative. There was a significant difference between the two groups (P<0.01), a significant difference among each part of the chronic inflammatory mocusa of lacrimal sac. CONCLUSION: VEGF may play an important role in hyperplasia of inflammatory mucosa of lacrimal sac.