| Abstract: | Estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid (GR) receptor levels were assayed in 70 malignant epithelial ovarian tumors from untreated patients and in 23 malignancies from those receiving preoperative chemotherapy. Both PR+ and AR+ frequency and their mean levels in tumor were found to be relatively lower after preoperative chemotherapy. The prognostic significance of receptor status in tumor was identified: the efficacy of combined chemotherapy in PR- and RA- tumor patients was much lower as compared with PR+ and RA+ tumors; a 2-year recurrence-free survival of 12.5% and median duration of remission of 6 months were observed in the former group, while in the latter the disease-free survival rate was as high as 66.7%, and a median duration of remission had not been reached at 24 months of follow-up. |
