Repeated administrations of rituximab along with steroids and immunosuppressive agents in refractory steroid-resistant nephrotic syndrome期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Repeated administrations of rituximab along with steroids and immunosuppressive agents in refractory steroid-resistant nephrotic syndrome

Authors:	Shuichiro Fujinaga Koji Sakuraya

Affiliation:	1.Division of Nephrology,Saitama Children’s Medical Center,Saitama-city, Saitama,Japan;2.Department of Pediatrics,Juntendo University School of Medicine,Tokyo,Japan

Abstract:	Background A recent randomized control trial in children with steroid-resistant nephrotic syndrome revealed that two doses of rituximab did not reduce proteinuria. Case characteristics A 14-month-old boy developed refractory steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis. Observation The patient achieved complete remission 11 months after disease onset following eight doses of rituximab combined with steroids and cyclosporine. Message Long-lasting B cell depletion with repeated rituximab administrations may be required to achieve complete remission in patients with steroid-resistant nephrotic syndrome and massive proteinuria.

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