Successful allogeneic hemopoietic stem cell transplantation in a case of Wiskott–Aldrich syndrome and non‐Hodgkin lymphoma |
| |
Authors: | Betul Tavil Arzu Yazal Erdem Fatih Azik Pamir Isik Ayse Metin Suna Emir Duygu Uckan Bahattin Tunc |
| |
Institution: | 1. Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, , Diskapi, Ankara, Turkey;2. Department of Pediatric Immunology, Ankara Children's Hematology and Oncology Hospital, , Diskapi, Ankara, Turkey;3. Department of Pediatric Oncology, Ankara Children's Hematology and Oncology Hospital, , Diskapi, Ankara, Turkey |
| |
Abstract: | WAS is a severe X‐linked recessive disorder characterized by microthrombocytopenia, eczema, and immunodeficiency. A six‐yr‐old boy with WAS diagnosed as B‐cell NHL (Stage III) localized in the liver who underwent successful HSCT from HLA‐one antigen mismatch sibling donor has been presented here. His conditioning regimen included ATG, busulfan, and fludarabine. He received 2.3 × 106/kg CD 34(+) stem cells and 11 × 108/kg nucleated cells at day 0. Neutrophil engraftment was achieved at day +14 and platelet engraftment at day +20. He has been in CR for more than two yr after transplantation. Thus, HSCT is an effective treatment for children with WAS even after development of lymphoma. |
| |
Keywords: | pediatrics allogenic stem cell transplantation Wiskott‐Aldrich syndrome non‐Hodgkin lymphoma |
|
|