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Successful allogeneic hemopoietic stem cell transplantation in a case of Wiskott–Aldrich syndrome and non‐Hodgkin lymphoma
Authors:Betul Tavil  Arzu Yazal Erdem  Fatih Azik  Pamir Isik  Ayse Metin  Suna Emir  Duygu Uckan  Bahattin Tunc
Institution:1. Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, , Diskapi, Ankara, Turkey;2. Department of Pediatric Immunology, Ankara Children's Hematology and Oncology Hospital, , Diskapi, Ankara, Turkey;3. Department of Pediatric Oncology, Ankara Children's Hematology and Oncology Hospital, , Diskapi, Ankara, Turkey
Abstract:WAS is a severe X‐linked recessive disorder characterized by microthrombocytopenia, eczema, and immunodeficiency. A six‐yr‐old boy with WAS diagnosed as B‐cell NHL (Stage III) localized in the liver who underwent successful HSCT from HLA‐one antigen mismatch sibling donor has been presented here. His conditioning regimen included ATG, busulfan, and fludarabine. He received 2.3 × 106/kg CD 34(+) stem cells and 11 × 108/kg nucleated cells at day 0. Neutrophil engraftment was achieved at day +14 and platelet engraftment at day +20. He has been in CR for more than two yr after transplantation. Thus, HSCT is an effective treatment for children with WAS even after development of lymphoma.
Keywords:pediatrics  allogenic stem cell transplantation  Wiskott‐Aldrich syndrome  non‐Hodgkin lymphoma
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