Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica |
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Authors: | Ly Ngoc P Soto-Quirós Manuel E Avila Lydiana Hunninghake Gary M Raby Benjamin A Laskey Daniel Sylvia Jody S Celedón Juan C |
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Institution: | Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA. |
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Abstract: | BACKGROUND: Little is known about the determinants of airway hyperresponsiveness (AHR) among children with asthma in Hispanic America. METHODS: We examined the relations among selected familial and environmental factors, markers of allergy, spirometric measures of lung function, and AHR in a cross-sectional study of 403 Costa Rican children with asthma between the ages of 6 and 14 years. Study participants completed a protocol that included questionnaires, spirometry, measurements of serum total and allergen-specific IgE, peripheral blood eosinophil count, and body mass index, and the assessment of airway responsiveness to methacholine (ie, a methacholine challenge test MCT]). AHR to MCT was defined as the provocative dose of methacholine causing a 20% fall in FEV(1). Linear regression was used for the univariate and multivariate analyses. RESULTS: Of the 403 asthmatic children who underwent an MCT, 350 (86.8%) had AHR to methacholine. In a multivariate analysis, paternal asthma (p = 0.004), parental report of mold/mildew in the child's home (p = 0.04), FEV(1)/FVC ratio (p < 0.0001), and a positive IgE response to Der p 1 (p = 0.008) were significantly associated with AHR among Costa Rican children with asthma. CONCLUSION: Our results suggest that paternal asthma and environmental exposure to mold/mildew are strong determinants of AHR in Costa Rican children with asthma. FEV(1)/FVC ratio may be a useful measure of AHR (a marker of asthma severity) among Costa Ricans and other Hispanic Americans for whom reference values for FEV(1) are not currently available. |
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Keywords: | airway hyperresponsiveness asthma Hispanics mold paternal asthma AHR"} {"#name":"keyword" "$":{"id":"cekeyw80"} "$$":[{"#name":"text" "_":"airway hyperresponsiveness BMI"} {"#name":"keyword" "$":{"id":"cekeyw120"} "$$":[{"#name":"text" "_":"body mass index MCT"} {"#name":"keyword" "$":{"id":"cekeyw160"} "$$":[{"#name":"text" "_":"methacholine challenge test |
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