| 氧自由基对胃粘膜细胞膜的损伤作用 |
| |
| 引用本文： | 李铁,张席锦. 氧自由基对胃粘膜细胞膜的损伤作用[J]. 北京大学学报(医学版), 1993, 0(5) |
| |
| 作者姓名： | 李铁 张席锦 |
| |
| 作者单位： | 北京医科大学生理学教研室(李铁)，北京医科大学生理学教研室(张席锦) |
| |
| 摘 要： | 当黄嘌呤氧化酶—黄嘌呤(XO—X)产生的氧自由基引起离体孵育的胃粘膜细胞损伤时,细胞的丙二醛(MDA)含量随XO浓度的加大而增高,并与细胞的损伤程度呈平行关系。受损细胞的膜流动性下降及溶血性卵磷脂与卵磷脂的比值(LPC/PC)降低。提示,XO—X产生的氧自由基引起的胃粘膜细胞膜物化特性的改变是其导致细胞损伤的机理之一。
|
| 关 键 词： | 氧自由基 胃粘膜细胞 脂质过氧化 膜流动性 磷脂 |
THE INJURIOUS EFFECT OF OXYGEN RADICALS ON THE MEMBRANE OF GASTRIC MUCOSAL CELLS |
| |
| Li Tie,Zhang Xijin. THE INJURIOUS EFFECT OF OXYGEN RADICALS ON THE MEMBRANE OF GASTRIC MUCOSAL CELLS[J]. Journal of Peking University. Health sciences, 1993, 0(5) |
| |
| Authors: | Li Tie Zhang Xijin |
| |
| Affiliation: | Li Tie;Zhang Xijin Department of Physiology |
| |
| Abstract: | When the cultured isolaetd gastric mucosal cells were injured by oxygen radicals produced by xan-thine oxidase(XO)-xanthine(X) system, the content of malondialdehyde (MDA) in the cells increased ina dosedependent manner with the concentration of XO, and paralleled to the intensity of cellular in-jury The membrane f1uidity and ratio between lysophosphatidylcholine and phosphatidylcholine(LPC/PC) in the injured cells decreased. These suggested that the changes in the physico-chemical propertiesof the membrane induced by oxygen radicals mighs be one of the mechanisms of the cellular injury. |
| |
| Keywords: | Oxygen radicals Gastric mucosal cells Lipid peroxide Membrane fluidity Phospholipid |
| 本文献已被 CNKI 等数据库收录！ |
