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Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome |
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| Authors: | Ulrike Benninghoff Federica Cattaneo Alessandro Aiuti Alberto Flores-D'Arcais Carlo Gelmetti Matteo Viscardi Luciano Callegaro Massimiliano Mirolo Alessandro Ambrosi Maria Grazia Roncarolo Rosa Bacchetta |
| Institution: | Pediatric Clinical Research Unit, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan Italy;, Department of Pediatric Endocrine Unit, Vita-Salute University, Milan Italy;, Vita-Salute University, Milan Italy;, University Centre of Statistics for Biomedical Sciences, Vita-Salute University, Milan Italy;, Department of Pediatric Dermatology, 'Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena', Institute of Dermalogic Sciences, Universitàdegli studi, Milan Italy |
| Abstract: | We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug. |
| Keywords: | interferon-α hyper-IgE syndrome cytokines immunodeficiency eczema |