脑卒中患者血清HCY、IL-10及MMP-9水平与脑梗死体积的关系

目的：探讨急性脑梗死患者外周血清同型半胱氨酸（Hey）、白细胞介素10（IL-10）及血清基质金属蛋白酶-9（MMP-9）与脑梗死体积的关系。方法：选择急性脑梗死患者125例为观察对象，同期健康体检者为健康对照组（37例）。以ELISA法测定患者外周血清Hcy、IL-10及MMP-9水平；急性脑梗死患者按梗死体积被分为小梗死组（≤5cm，47例），中梗死组（5～15cm，41例），大梗组（≥15cm，37例）；比较不同梗死体积Hcy、IL-10及MMP-9水平的变化。结果：与健康对照组比较，急性脑梗死组患者MMP-9、Hcy水平显著升高；IL-10显著降低。外周血清Hcy水平：大梗死组的显著高于小梗死组和中梗死组[（18．5±4．2）μmol／L比（16．11±3．5）μmol／L、（16．79±3．4）μmol／L、P〈0．01，P〈0．053；外周血清MMP-9水平：大梗死组及中梗死组的均明显高于小梗死组[（256±35）ng／ml、（238±26）ng／ml比（164±35）ng／ml，P〈0．01，P〈0．053；IL-10水平：大梗死组的明显低于小梗死和中梗死组[（0．31±0．12）ng／ml、（0．59±0．15）ng／ml比（0．60±0．17）ng／ml，P均〈0．01]。结论：同型半胱氨酸、白细胞介素10及血清基质金属蛋白酶-9水平与急性脑梗死的发病有关系，可反映脑梗死的危险程度。

Relationship among serum levels of homocysteine, interleukin-10, matrix metalloproteinase-9 and infarct volume in patients with cerebral infarction

Objective： To explore relationship among serum levels of homocysteine （Hey）, interleukin （1L） -10, ma-trix metalloproteinase （MMP） -9 and infarct volume in patients with acute cerebral infarction （CI）. Methods： A total of 125 acute CI patients were regard as acute CI group, and another 37 healthy subjects were enrolled as health-y control group. Enzyme linked immunosorbent assay （ELISA） method was used to measure serum levels of Hcy, IL-10 and MMP-9 of subjects; according to infarct volume, acute CI patients were divided into small infarction group （≤5cm^3, n=47）, medium infarction group （5-15 cm^3, n=41） and large infarction group （≥15cm^3, n= 37） ; changes of levels of Hcy, IL-10 and MMP-9 were compared among all groups. Results： Compared with healthy control group, there were significant increase in levels of MMP-9 and Hcy, and significant decrease in IL-10 level in acute CI group. Compared with small and medium infarction groups, there was significant increase in serum Hcy level [ （16.11±3. 5） μmol/L, （16.79±3.4） μmol/L vs. （18.5±4.2） μmol/L, P〈0.01, P〈0. 053 in large infarc-tion group, Compared with small infarction group, there was significant increase in serum MMP-9 level [ （161±27） ng/ml vs. （238±26） ng/ml, （256±35） ng/ml, P〈0. 05, P〈0.01], Compared with small infarction group and medium infarction group, there were significant decrease in IL-10 level [ （0.60±0.17） ng/ml vs. （0. 59±0.15） ng/ ml, （0. 31±0. 12） ng/ml, P〈0. 01 both] in large infarction groups. Concision： Serum levels of homocysteine, in-terleukin-10 and matrix metalloproteinase-9 are related to onset of acute cerebral infarction, and may reflect risk de-gree of cerebral infarction.