中药枳壳提取物对大鼠不同肠段平滑肌运动功能的影响

【目的】观察枳壳提取物对大鼠十二指肠、空肠、回肠及结肠不同肠段平滑肌收缩功能的影响。【方法】采用离体肠平滑肌实验方法,利用BL-410生物机能分析仪记录给药前后大鼠各肠段平滑肌的收缩幅度和频率,探讨不同浓度枳壳提取物对各肠段收缩的影响。【结果】随着枳壳提取物浓度的不断增加,对正常大鼠十二指肠、空肠、回肠及结肠平滑肌的自发性收缩表现出显著的抑制作用,并能够拮抗乙酰胆碱所致的平滑肌收缩功能的亢进,使阿托品所致平滑肌的舒张作用进一步增强。而枳壳提取物对十二指肠、空肠、回肠及结肠4个肠段平滑肌的舒张作用的强度不同,其中对回肠的作用最强。【结论】枳壳提取物对大鼠离体肠平滑肌的舒张作用强弱表现为回肠>空肠>结肠>十二指肠。

Effects of extract of Fructus Aurantii on the mobility of different parts of intestine of rat

【Objective】To investigate the effect of extract of Fructus Aurantii on duodenum,jejunum,ileum and colon of rat【.Method】 The BL-410 experimental system was used to study the mobility of duodenum,jejunum,ileum and colon of rat,and the contractive amplitude,frequency,mobility of the different smooth muscle in rat caused by the extract of Fructus Aurantii were recorded.【Results】 The extract of Fructus Aurantii could inhibit the spontaneous movement of smooth muscle of the normal rat.The results showed that with the increasing dose of the extract,the mobility of duodenum,jejunum,ileum and colon were resisted on gastrointestinal hyper function by acetylcholine and in coordination with the relaxation activity induced by atropine.Among four parts of intestine,it displayed that the strongest inhibition was in the ileum.【Conclusion】The inhibition of the extract of Fructus Aurantii on the different parts of the intestines were displayed as： ileumjejunumcolonduodenum.