| 促红细胞生成素对肾缺血再灌注损伤的保护作用 |
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| 引用本文： | 张渝华,张勤,郭东阳.促红细胞生成素对肾缺血再灌注损伤的保护作用[J].西南国防医药,2005,15(6):589-591. |
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| 作者姓名： | 张渝华 张勤 郭东阳 |
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| 作者单位： | 1. 成都军区总医院肾内科,四川,成都,610083
2. 成都军区总医院药学部 |
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| 摘 要： | 目的：探讨促红细胞生成素（Erythropoietin，Epo）对肾缺血再灌注损伤的保护作用。方法：观察Epo对肾缺血再灌注损伤大鼠血丙二醛（MDA）、肌酐（Cr）、尿素氮（BUN）和肾组织匀浆超氧化物歧化酶（SoD）、白介素-6（IL-6）变化。结果：Epo治疗组血浆MDA、Cr、BUN水平较缺血再灌注组显著下降（P〈0．05）；肾组织匀浆SOD显著升高、IL-6显著降低（P〈0．05）。结论：Epo可提高SOD，降低IL-6对肾缺血再灌注损伤具有保护作用.
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| 关 键 词： | 肾损伤 缺血再灌注 促进红细胞生成素 |
| 文章编号： | 1004-0188（2005）06-0589-03 |
| 收稿时间： | 2005-05-12 |
| 修稿时间： | 2005年5月12日 |
Protective effects of erythropoietin on renal ischemia reperfusion injury |
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| ZHANG Yu-hua,ZHANG Qin,GUO Dong-yang.Protective effects of erythropoietin on renal ischemia reperfusion injury[J].Medical Journal of National Defending forces in Southwest China,2005,15(6):589-591. |
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| Authors: | ZHANG Yu-hua ZHANG Qin GUO Dong-yang |
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| Abstract: | Objective: To study the protective effects of erythropoietin(EPO) on renal ischemia/reperfusion(I/R) injury.Methods: The model of renal I/R injury was treated with EPO and then the levels of plasma malondialdehyde(MDA),creatine(Cr),blood urea nitrogen(BUN) and tissue superoxide dismutase(SOD),interleukin-6(IL-6) were determined in rats. Results: The levels of MDA,Cr,BUN and tissue IL-6 were significantly lower in EPO group than those in I/R group(P<0.05),but the level of SOD was higher in EPO group than in I/R group(P<0.05).Conclusion: EPO has protective effects on renal I/R injury in rats,because it can increase SOD and decrease IL-6. |
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| Keywords: | erythropoietin ischemia/reperfusion kidney |
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