功能性消化不良患者精神心理因素与十二指肠肥大细胞的相关性

目的探讨精神心理因素和十二指肠黏膜肥大细胞(mast cell,MC)在功能性消化不良(functional dyspepsia,FD)中的作用。方法应用医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)评定焦虑(HADS-A)和抑郁积分(HADS-D),甲苯胺蓝染色计数十二指肠黏膜MC总数及脱颗粒比率。直线相关分析HADS-A、HADS-D与十二指肠黏膜MC的相关性。结果 FD患者HADS-A和HADS-D显著高于对照组(P<0.05),十二指肠黏膜MC显著高于对照组(P<0.01),MC脱颗粒比率显著高于对照组(P<0.001)。HADS-A、HADS-D与十二指肠MC计数、脱颗粒比率呈正相关(P<0.05)。结论 FD患者的精神心理异常,可能与十二指肠黏膜MC的数目及脱颗粒比率增高有关。

Relationship between psychosocial factors and duodenal mast cells in patients with functional dyspepsia

Objective To explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of functional dyspepsia(FD).Methods The Hospital Anxiety and Depression Scale(HADS) was used to evaluate the psychosocial status of FD patients.Mast cell abundance and degranulation rates in the bulb(D1) and second part(D2) of the duodenum were obtained on toluidine blue-stained sections.The relationships among the scores of anxiety(HADS-A) and depression(HADS-D),the MC counts and MC degranulation rates in D1 and D2 were studied.Results HADS-A and HADS-D scores were significantly higher in FD patients than in controls(P<0.05).This was also true for duodenal mast cell abundance(P<0.01) and degranulation rates(P<0.001).Scores of HADS-A and HADS-D were positively correlated with the duodenal mast cell abundance and degranulation rates.Conclusion The abnormal psychosocial status of FD patients is correlated with the increased abundance and degranulation rates of duodenal mast cells.