肉芽肿性小叶性乳腺炎诊治进展

肉芽肿性小叶性乳腺炎(GLM)困扰着许多女性患者，临床上对其缺乏充分认识，易出现误诊。研究表明，自身免疫反应可能介导该疾病的发生，激素及免疫抑制剂治疗可能有效，保守治疗或可避免手术。最近研究发现GLM病变处IgG4+浆细胞及CD4+或CD8+淋巴细胞浸润并伴有血清高水平IgG4，为研究GLM与IgG4相关自身免疫性疾病间的关系提供了新的证据，也提出了是否应重新界定GLM的问题。本文综述了GLM的病因假说、临床病理特点、诊断及治疗的最新研究进展，为认识这一疾病展开新的视野。

Granulomatous lobular mastitis: progress in diagnosis and treatment

Many women suffer from granulomatous lobular mastitis(GLM) which is often to be misdiagnosed because of less of awareness of it.This form of mastitis is associated with autoimmune reaction and responds well to steroids and immunosuppressive therapy,and thus conservative treatment may be the botter choice.According to recent studies,GLM showed specific clinicopathological features including lobular centric inflammation with giant cells,infiltration of IgG4+ plasma cells and CD4+ or CD8+ lymphocytes,and a high level of serum IgG4.This study provides a new evidence for the relationship between GLM and IgG4-related autoimmune diseases,and also put forward a question whether GLM should be redefined.The aim of this review is to summarize the etiology,clinical symptoms,pathology,and current research progresses about diagnosis and therapy of GLM.