SATB1与HER2表达和乳腺癌分化程度的相关性

目的 检测特异性核基质结合蛋白(SATB1)和人表皮生长因子受体2(HER2)在乳腺癌中的表达，探讨其与乳腺癌分化程度的关系。方法 应用免疫组织化学方法检测乳腺癌患者SATB1和HER2蛋白的表达，使用荧光原位杂交(FISH)方法检测HER2基因扩增状态，分析二者表达的相关性及与临床病理参数之间的关系。结果 乳腺癌中存在SATB1与HER2的高表达，且二者呈正相关(r=0.425，P＜0.05)。SATB1和HER2的表达与肿瘤组织分级有关,其共表达的肿瘤组织具有更高的组织学分级，与Ⅲ级乳腺癌相关(r=0.472,P＜0.05)。结论 SATB1可调节乳腺癌中HER2的表达，SATB1/HER2双阳性表达是乳腺癌低分化的一个标志。

Correlation between SATB1 and HER2 expressions and the tumor grade in breast cancer

Objective To test the expressions of special AT rich sequence binding protein(SATB1) and human epidermal growth factor receptor 2(HER2),and to investigate their relationships with the differentiation of breast carcinoma.Methods Expressions of SATB1 and HER2 were evaluated by immunohistochemistry method.Fluorescence in situ hybridization(FISH) was used to test the HER2 gene amplification.The association between SATB1 and HER2 expressions and their relationships with the clinicopathologic features of breast carcinoma were analyzed.Results SATB1 and HER2 were highly expressed in breast carcinoma,and there were a significant correlation between the two(r=0.425,P<0.05).SATB1 and HER2 expressions were related to the tumor histological grade,and the histological grade of double positive samples was higher.Co-expression of them was significantly correlated with tumor grade Ⅲ in breast cancer(r=0.472,P<0.05).Conclusion SATB1 could regulate the expression of HER2,and SATB1/HER2 positive co-expression might be a poorly differentiated marker in the breast cancer.