血清脂联素、瘦素水平与乳腺癌相关性的初步研究

目的探讨血清脂联素、瘦素水平与乳腺癌的相关性。方法通过流行病学调查收集新发乳腺癌病例123例,剔除拒绝采集血液标本的病例后得到乳腺癌患者43例。以该43例乳腺癌患者为病例组,以同社区、同年龄(±3岁)为配对标准,选择经临床检查或病理诊断排除乳腺癌的女性为对照组,按照1∶1进行配对,最终入组病例及对照共43对。酶联免疫吸附法(ELISA)测定血清脂联素、瘦素水平,进行配对t检验、χ2检验、条件Logistic回归分析等统计学处理。结果病例组血清脂联素水平低于对照组,瘦素水平高于对照组,脂联素/瘦素比值(A/L)低于对照组。Logistic回归分析结果显示,A/L与乳腺癌密切相关(OR=6.33,95%CI:1.87～21.40,P<0.01)。结论人群中乳腺癌患者较非乳腺癌患者有较低的血清脂联素水平,较高的血清瘦素水平。A/L与乳腺癌的发病具有明显相关性,此相关性明显优于单独脂联素或瘦素与乳腺癌发病的相关性。

Associations between breast cancer and serum levels of adiponectin and leptin

Objective To investigate the association between breast cancer and serum levels of adiponectin and leptin.Methods Data from 123 patients who were histologically diagnosed as breast cancer were collected through an epidemiological survey in China.Discounting the patients who refused to have blood specimens collected,43 patients with breast cancer were enrolled.Then in the ratio of 1∶ 1,43 women who attended the physical check-up but without evidence of breast cancer were included as the control.The pairing standards were of the same communities and ages(±3 years).Serum levels of adiponectin and leptin were tested by enzyme-linked immunosorbent assay(ELISA) for final statistical analysis,such as paired t-test,χ2 test and conditional logistic regression analysis.Results Compared to the control group,serum levels of leptin in breast cancer patients were increased,while serum levels of adiponectin and the adiponectin/leptin ratio were decreased.After conditional logistic regression analysis,the adiponectin/leptin ratio was found to be significantly correlated to breast cancer(OR=6.33,95%CI:1.87~21.40,P<0.01).Conclusion The breast cancer group had lower serum adiponectin levels and higher serum leptin levels than the control group.The adiponectin/leptin ratio was more closely correlated to the breast cancer compared with the adiponectin or leptin levels alone.