| 肾移植大鼠慢性排斥反应模型的建立 |
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| 引用本文： | 冯宁翰,钱立新,华立新,夏国伟,吴军,贺伟峰,宋宁宏,乔迪,徐正铨,张炜,吴宏飞,眭元庚,FENG Ning-han,QIAN Li-xin,HUA Li-xin,XIA Guo-wei,WU Jun,HE Wei-feng,SONG Ning-hong,QIAO Di,XU Zheng-quan,ZHANG Wei,WU Hong-fei,SUI Yuan-gen.肾移植大鼠慢性排斥反应模型的建立[J].南京医科大学学报,2005,25(11):796-798. |
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| 作者姓名： | 冯宁翰 钱立新 华立新 夏国伟 吴军 贺伟峰 宋宁宏 乔迪 徐正铨 张炜 吴宏飞 眭元庚 FENG Ning-han QIAN Li-xin HUA Li-xin XIA Guo-wei WU Jun HE Wei-feng SONG Ning-hong QIAO Di XU Zheng-quan ZHANG Wei WU Hong-fei SUI Yuan-gen |
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| 作者单位： | 南京医科大学第一附属医院泌尿外科肾移植中心 江苏南京210029
(冯宁翰，钱立新，华立新，夏国伟，宋宁宏，乔迪，徐正铨，张炜，吴宏飞)，第三军医大学西南医院全军烧伤研究所 重庆400038
(吴军，贺伟峰)，南京医科大学第一附属医院泌尿外科肾移植中心 江苏南京210029(眭元庚) |
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| 基金项目： | 国家自然科学基金资助项目(30200264) |
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| 摘 要： | 目的:建立一种方便、实用的慢性器官移植排斥反应模型,为研究器官移植后慢性排斥反应的发病机制、预防和治疗提供平台。方法:以近交系F344大鼠和近交系Lewis大鼠作为供、受体,取供体的双肾作为供肾,借助静脉支架管,行供体的静脉与受体肾静脉的端端吻合,肾动脉与腹主动脉行端侧吻合。施行原位异体肾移植。移植后即给与环孢素腹腔注射。并于术后4周后行病理检查。结果:所有手术均于60min内完成。所有的受体均存活超过60天,围手术期死亡数为零。受体无急性排斥反应发生。4周后可见典型的慢性排斥反应发生。结论:建立了大鼠慢性排斥反应肾移植模型。为研究慢性排斥反应的发生、进展和干预治疗提供了良好的平台。
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| 关 键 词： | 大鼠 肾移植 模型 排斥反应 |
| 文章编号： | 1007-4368（2005）001-0796-03 |
| 收稿时间： | 2005-06-10 |
| 修稿时间： | 2005年6月10日 |
Development of renal transplantation model of chronic rejection |
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| FENG Ning-han, QIAN Li-xin , HUA Li-xin,XIA Guo-wei, WU Jun,HE Wei-feng,SONG Ning-hong, QIAO Di, XU Zheng-quan,ZHANG Wei,WU Hong-fei, SUI Yuan-gen.Development of renal transplantation model of chronic rejection[J].Acta Universitatis Medicinalis Nanjing,2005,25(11):796-798. |
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| Authors: | FENG Ning-han QIAN Li-xin HUA Li-xin XIA Guo-wei WU Jun HE Wei-feng SONG Ning-hong QIAO Di XU Zheng-quan ZHANG Wei WU Hong-fei SUI Yuan-gen |
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| Institution: | 1.Department of Urology ,Center of Kidney Transplantation, the First Affiliated Hospital of NJMU, Nanjing 210029;2.Research Institute of Burn,Southwest Hospital ,the Third Minitary Medical University, Chongqing 400038, China |
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| Abstract: | Objective: To establish an economic and feasible rat renal transplantation model of chronic rejection. Methods: Inbred F344 and Lewis rats were used as the donors and the recipients. Both kidneys were removed from the donors. With the help of PTCA tube, an end-to-end anastomosis of vein was operated .After transplantation,recipients were received ciclosporin every day.Results: All operations were finished within 60 min. No recipients died during operation. No acute rejection evidence was seen. Chronic rejection could be seen obviously 4 weeks after operation. Conclusion: The newly established method is feasible and reliable. The good model of studying chronic rejection were offered. |
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| Keywords: | rats kidney transplantation model rejection |
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