代谢综合征患者动态血压有关指标与冠状动脉病变的相关性分析

目的探讨动态收缩压（SBP）、舒张压（DBP）、平均动脉压（MBP）、脉压（PP）、脉压指数（PPJ）与代谢综合征（MS）患者冠状动脉病变严重程度相关性，评价各指标对冠状动脉病变的预测价值。方法对204例患者行冠状动脉造影（CAG），分析冠状动脉狭窄程度，并计算冠状动脉病变血管数和冠状动脉病变评分；同时行动态血压监测（ABPM）。分为非CHD和CHD组，按PPI≤0．40、0．41-0．50、0．51—0．60、〉0．60分为4组，按PP≤40mmHg、41-60mmHg、61—80mmHg、〉80mmHg分为4组，比较各组间冠状动脉病变程度。结果非CHD和CHD组在年龄、血脂、体重指数、SBP、PP、PPI上差异有统计学意义（P〈0．05）；PP和PPI组在冠心病发生率、冠状动脉病变的血管数、评分和冠脉狭窄程度上均差异有统计学意义（P〈0．05 or P〈0．01）；MS患者的CHD发生率及病变程度与SBP、PP、PPI显著相关（P〈0．01），与PPI相关性最为最著。结论在动态血压各指标中，PP、PPI、SBP与冠状动脉病变密切相关，可作为代谢综合征患者二级预防靶点。

The analysis of the correlation between relevant indexes of ambulatory blood pressure in patients with metabolic syndrome and coronary artery disease

Objective To investigate the correlation between SBP,DBP,MBP,PP,PPI and the severity of coronary artery disease of metabolic syndrome(MS)patients,to evaluate the predictive value of indexes aasociated to coronary artery disease.Methods We analyzed the level of coronary artery stenosis in 204 patients through law coronary angiography(CAG),calculated the number of coronary vasculars with diseases,evaluated the score of coronary vasculars with diseases and examined these patients with ABPM.These cases were divided into.different groups aecording to different criterions Then compared the level of coronary artery stenosis with each group.Results There were significant differences between two groups of non-CHD and CHD in age,serum lipids,body magg index,SBP,PP and PPI(P＜0.05),there were significant differences between two groups of PP and PPI in the incidence of CHD,in the number and the score of coronary vascular with diseases and the level of coronary artery stenosis(P＜0.05 or P＜0.01).The incidence of CHD and the extent of coronary artery stenosis have significant correlation to SBP,PP,PPI(P＜0.01)and correlation to PPI is particularly notable.Conclusion Among the indexes of ambulatory blood pressure,the PP,PPI,SBP are closely related to coronary artery disease,they can be used as secondary preventable targets in MS patients.