| Abstract: | To review the implication of CXCR4 for gastrointestinal cancer,a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers.Search terms applied were "cancer,malignoma,esophageal,gastric,colon,colorectal,hepatic,pancreatic,CXCR4,SDF-1α,and SDF-1β"; CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas.The CXCR4 ligand SDF-1α might act as "chemorepellent"while SDF-1β might act as "chemorepellent" for CTLs,inducing tumor rejection.The paracrine expression of SDF-1α was furthermore closely associated with neoangiogenesis.CXCR4 and its ligands influence the dissemination,immune rejection,and neoangiogenesis of human gastrointestinal cancers.Inhibition of CXCR4 might be an interesting therapeutic option. |
