经鼻持续气道正压通气治疗早产儿肺透明膜病的临床研究

目的探讨经鼻持续气道正压通气(NCPAP)在治疗早产儿早期肺透明膜病的治疗效果及安全性。方法对早产儿早期肺透明膜病经头罩吸氧下临床表现和低氧血症未改善者共28例采用NCPAP治疗。观察NCPAP治疗前后的临床表现和动脉血气分析变化。结果应用NCPAP治疗6h后,24h后动脉血气氧分压,经皮血氧饱和度较治疗前上升,两者比较差异具统计学意义(P<0.05);治疗6h后,24h后动脉血气二氧化碳分压,呼吸频率较治疗前降低,两者比较差异具有统计学意义(P<0.05)。本组有效22例,无效6例,总有效率78.58%。28例治疗过程中未发现气胸,鼻粘膜糜烂、感染等并发症。结论NCPAP治疗早产儿早期肺透明膜病安全用效,值得基层医院推广应用。

Clinical Research of Nasal Continuous Positive Airway Pressure on Treatment of Premature Infants with Hyaline Membrane Disease

Objective To invesgate the effcets and safety about nasal continuous positive airway pressure(NCPAP) on treatment of premature infants with hyaline membrane disease.Methods 28 premature infants with hyaline membrane diseases whose clinical manifestation and hypoxemia did not improved by oxygen supply from head nets were selected to be treated by NCPAP.The clinical manifestations and the changes of arterial blood gas analysis were observed before and after treatments.Results The oxygen partial pressure of arterial blood gas improved in 6 hours and 24 hours after treatment compared with those before treatment,so there were significant differences between two groups(P <0.05).The carbon dioxide partial pressure of arterial blood gas and the respiratory frequency cutted down in 6 hours and 24 hours after treatment compared with those before treatment,so there were significant differences between two groups(P <0.05).There were 22 cases with efficient effects and 6 cases with inefficient effects.No case was found to be with the complications of pneumothorax,nasal mucosal erosion and infection.Conclusion The NCPAP is safe in the treatment on premature infants with hyaline membrane disease,which deserves application in local hospitals.