2006和2011年体检人群空腹血糖和血尿酸纵向变化

目的：通过分析固定体检人群在2006和2011年健康体检空腹血糖（GLU）和血尿酸（UA）结果，了解体检人群近6年GLU和UA水平和分布特征变化，为更好地做好干部保健服务提供依据。方法：筛选2006和2011年在我院体检者10741名为此次调查对象，按2011年体验时的年龄分组，比较各组不同性别之间GLU和UA水平变化情况。结果：2006年体检人群GLU平均值为（5．48±0．95）mmol·L^-1，2011年增至（5．71±1．10）mmol·L^-1，两者差异有统计学意义（t=18．614，P=0．000）。2006年体检人群空腹血糖调节受损（IFG）检出率为23．5％，DM（糖尿病）检出率为4．5％；而2011年IFG检出率为33．6％（∥=315．4，P=0．000），DM检出率为7．3％（χ2=132．1，P=0．000）。2006年体检人群男性IFG检出率为27．2％，DM检出率为5．6％；2011年男性IFG检出率增至38．2％（χ2=262．0，P=0．ooo），DM检出率增至9．3％（χ2=133．8，P=0．000）。2006年体检人群女性IFG检出率为14．7％，DM检出率为1．8％；2011年IFG检出率增至22．6％（χ2=68．643，P=0．000），DM检出率增至2．7％（χ2=9．240，P=0．002）。2006年体检人群UA平均值为（349．91±84．86）μmol·L^-1，高尿酸血症检出率为21．6％；2011年体检人群UA平均值为（360．60±86．68）μmol·L^-1，高尿酸血症检出率为26．5％。2011年体检人群UA平均水平（t=12．941，P=0．000）及体检人群高尿酸血症检出率（χ2=87．806，P=0．000）明显高于2006年。在IFG期UA平均水平随血糖升高而升高，而当进展到DM阶段，UA平均水平有所下降，但仍高于GLU正常水平的体检人群。结论：过去6年中IFG、DM和高尿酸血症检出率明显增加，且男性远高于女性；高尿酸血症与IFG及DM发病率关系密切。

Longitudinal changes of GLU and UA among health check-up in 2006 and 2011

Objective： In order to study changes of GLU and UA among the fixed health check subjects, a number of 10 741 blood data in 2006 and 2011 were analyzed. Methods：10 741 health check-up subjects were divided into different groups according to age in 2011. Then the average levels of GLU and UA were computed. The ratioes of IFG, DM and hyperuricemia among groups were compared. Results ： The average level of GLU for total subjects in2006 was （5.48 ± 0.95 ） mmol · L ^- 1, and up to （5.71 ± 1.10） mmol· L^- 1 in 2011. The average level of GLU for total subjects in 2011 had an obvious uptrend compared to that in 2006 （t = 18. 614, P =0.000）. The ratio of IFG in 2006 was 27.2% for man, in 2011 was 38.2% （ χ2 =262.0, P =0.000）, for woman in 2006 was 14.7% , and in 2011 was 22.6% （χ2 = 68. 643, P = 0. 000）. The ratio of DM in 2006 for man was 5.6% , in 2011 was 9.3% （χ2 = 133.8 ,P =0. 000）, for woman in 2006 was 1.8%, and in 2011 was 2.7% （χ2 =9. 240,P =0. 002）. The detection rates of IFG and DM in 2011 were apparently higher than those in 2006 （IFG χ2 =315.4, P = 0. 000. DM χ2 = 132.1, P =0.000）. The average level of UA for total subjects in 2006 was （349.91 ± 84.86） μmol · L-1, and was up to （360.60 ±86.68） μmol · L^-1 in 2011. The ratio of hyperuricemia for all subjects in 2006 was 21.6% , and up to 26.5% in 2011. The average level of UA for total subjects in 2011 had an obvious uptrend compared to the one in 2006 （t = 12.941, P =0. 000）. The detection rate of hyperuricemia in 2011 was apparently higher than the one in 2006 （χ2 = 87. 806, P = 0.000）. At the early stage of promoting GLU （ IFG）, the level of UA increased. To the stage of DM, UA decreased in some degree, but still kept a higher level. Conleusion： In the past six years, the detection rates of IFG, DM and hyperurieemia have increased apparently, especially for male. Hyperuricemia has a close relation with IFG and DM.